CCRI

CCRI/Transplantation Immunology (TI), part of the CCRI’s immunology branch, devotes its research to improve the safety of hematopoietic stem cell transplantation. The aim of TI is to develop strategies to generate immune competent but allo-tolerized cells to recipients in the post-transplant period when immune reconstitution is incomplete to bridge the risk of post-HSCT immunodeficiency.

The members of TI, the group leader, post-doctoral fellows, PhD and master students, combine their efforts to successfully establish robust and feasible approaches of educating donor T cells in the laboratory to mediate allo-specific tolerance, which means to assist the recipients’ protective immunity but not induce allo-reactivity, which occurs in the direction of graft-versus-host disease.

Within MODICELL, bioinformatics analyses of T cells will be employed to fully understand and exploit the complexity of molecular regulation in T cell tolerance to foster the development of safe adoptive transfer strategies which will finally benefit the patients in need. 

CCRI IN THE MODICELL PROJECT

CCRI/Transplantation Immunology will in its experimental approach co-culture T cells with allogeneic stimulator cells to simulate transplantation by utilizing hypothetical tolerogenic conditions.

Then, the putatively allo-tolerized T cells will be subjected to broad immunological and bioinformatics analyses for the purpose of getting a holistic perspective on key patterns and pathways which are essential for identification of tolerance development.

Bioinformatics analyses will be done in collaboration with SME Significo/Finland. Immune modelling will be used to validate the findings and will be performed in collaboration with the Bar-Ilan University in Israel. This knowledge will then be used for optimizing immune cell therapy after transplantation.

PEOPLE INVOLVED

 

 Andreas Heitger    Nuno Andrade    Birgit Jurgens
 Andreas Heitger    Nuno Andrade    Birgit Jürgens

coordinator of MODICELL

team leader Transplantation Immunology

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post doctoral fellow

human in vitro studies

 

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email:

 David Heja    Alex Dohnal    Stefan Weinberger
 David Heja  

 Alexander Dohnal

   Stefan Weinberger

post doctoral fellow

Marie-Curie fellow

human in vitro studies

 

post-doctoral fellow

human, murine in vitro/in vivo studies

 

   
 Barbara dillinger    Sarah Ahmadi    
 Barbara Dillinger    Sarah Ahmadi    

PhD student

human in vitro studies

 

 

PhD student

murine in vivo/in vitro studies

   

 

Project Title: MODICELL

Project No.: 285875

Coordinator: Andreas Heitger

Start: 01/01/2013

Duration: 48 months

Contact: office@modicell.eu

CORDIS: Project Details


LEGAL DETAILS & CONTACT

The Project recieves funding from the European Union FP7-People Programme under grant agreement n° 285875

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