T-CELL THERAPY

WHY T-CELL THERAPY

Immune cell therapies have become a main focus of current research because of their presumed property of promoting effective, specific and patient-tailored immune modulatory activity adapted to patients’ needs for the treatment of diseases featuring major immune disturbances including cancer or transplant.

BASIC KNOWLEDGE

T lymphocytes (T cells) are a cell population critically involved in guiding immune responses for maintaining the integrity of the organism. These include mounting powerful effector immune responses upon invasion of infectious pathogens, or inappropriate cell growth like cancer, on one hand.

On the other hand, T cells are supposed to mediate dampened immune responses to self-antigens which can emerge in the context of clearance of dead cell material or wound healing. Importantly, T cells do not act on their own but respond to antigens only upon presentation by specified antigen-presenting cells (APC).

In principle, every tissue resident cell can function as APC, however, the most effective APCs are dendritic cells (DC), which precisely inform T cells how to respond appropriate to the immunogenic stimulus. The APC/T cell interaction is regulated by complex mechanisms with seemingly opposing effects occurring at the same time.

The focus of MODICELL will be to advance the understanding of the APC/T cell interaction on a systems immunology level in order to identify patterns or pathways which are critical to the final outcome of T cell responses.

The ultimate vision of MODICELL is to use this knowledge for the development of effective T cell therapies, stimulating the paralyzed T cell immunity in the context of cancer or dampening the exaggerated T cell immunity in the context of transplant rejection.

Project Title: MODICELL

Project No.: 285875

Coordinator: Andreas Heitger

Start: 01/01/2013

Duration: 48 months

Contact: office@modicell.eu

CORDIS: Project Details


LEGAL DETAILS & CONTACT

The Project recieves funding from the European Union FP7-People Programme under grant agreement n° 285875

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